Marja M Hurley Selected Research

Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)

12/2021	Endogenous FGF-2 levels impact FGF-2/BMP-2 growth factor delivery dosing in aged murine calvarial bone defects.
1/2021	Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice.
1/2020	Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms.
1/2019	Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
1/2018	FGF23 Neutralizing Antibody Partially Improves Bone Mineralization Defect of HMWFGF2 Isoforms in Transgenic Female Mice.
1/2018	FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2.
10/2017	Inhibition of FGFR Signaling Partially Rescues Hypophosphatemic Rickets in HMWFGF2 Tg Male Mice.
12/2016	FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.
3/2016	Accelerated fracture healing in transgenic mice overexpressing an anabolic isoform of fibroblast growth factor 2.
3/2016	Age-Related Changes in FGF-2, Fibroblast Growth Factor Receptors and β-Catenin Expression in Human Mesenchyme-Derived Progenitor Cells.

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Marja M Hurley Research Topics

Disease

6	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2020 - 01/2010
6	Hypophosphatemia 01/2018 - 01/2010
4	Osteoarthritis 01/2020 - 12/2016
4	Osteomalacia 01/2018 - 01/2010
3	Bone Resorption 12/2021 - 06/2003
2	Hypophosphatemic Rickets 01/2018 - 10/2017
2	Neoplasms (Cancer) 10/2017 - 06/2007
2	Dwarfism 12/2014 - 01/2010
2	Rickets (Rachitis) 12/2014 - 01/2013
2	Osteoporosis 11/2012 - 08/2011
1	Fibrosis (Cirrhosis) 01/2021
1	Sarcopenia 01/2021
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2019
1	Osteophyte 12/2016
1	Closed Fractures (Closed Fracture) 03/2016
1	Tibial Fractures (Fracture, Tibial) 03/2016
1	Metabolic Bone Diseases (Osteopenia) 03/2016
1	Sickle Cell Anemia (Hemoglobin S Disease) 01/2016
1	Sickle Cell Trait 01/2016
1	Hypercalcemia (Milk Alkali Syndrome) 06/2003

Drug/Important Bio-Agent (IBA)

16	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 12/2021 - 06/2003
9	Protein Isoforms (Isoforms)IBA 01/2020 - 01/2010
4	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2021 - 10/2017
3	Parathyroid Hormone (Parathormone)IBA 12/2014 - 08/2011
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2019
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 12/2016
2	CateninsIBA 01/2018 - 03/2016
2	Phosphates (Orthophosphate)IBA 01/2013 - 01/2010
1	fibroblast growth factor 21IBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	LipidsIBA 01/2021
1	Insulin-Like PeptidesIBA 01/2019
1	Bone Morphogenetic Protein 4IBA 01/2019
1	Hypoxia-Inducible Factor 1IBA 01/2019
1	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 01/2019
1	DisintegrinsIBA 01/2019
1	Metalloproteases (Metalloproteinases)IBA 01/2019
1	ThrombospondinsIBA 01/2019
1	Immunoglobulin G (IgG)IBA 01/2018
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 10/2017
1	infigratinibIBA 10/2017
1	EnzymesIBA 12/2016
1	Green Fluorescent ProteinsIBA 03/2016
1	Aluminum Oxide (Sapphire)IBA 03/2016
1	Collagen Type I (Type I Collagen)IBA 03/2016
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2016
1	Fibroblast Growth Factor-23IBA 01/2013
1	Anabolic AgentsIBA 11/2012
1	butylbenzyl phthalate (benzyl butyl phthalate)IBA 06/2007
1	Cyclin D3IBA 06/2007
1	Endocrine DisruptorsIBA 06/2007

Therapy/Procedure

1	Precision Medicine 12/2021
1	Therapeutics 10/2017
1	Drug Therapy (Chemotherapy) 08/2011